FA T cell induces increased GVHD lethality. Fanca^−/− (A) and Fancd2^−/− (B) T cells induce higher GVHD lethality. 5 × 10⁶ of T cell deleted total BMCs (TCD) from WT mice plus 3 × 10⁶ T cells from either WT or FA mice were transplanted to lethally irradiated Balb/c recipients. Survival of recipients was monitored by Kaplan-Meier curve method. Each group includes 6 to 10 mice. (C) GVHD clinical scores were determined as a measure of GVHD severity in surviving animals on the indicated time points after allogeneic BMT. Data are presented as means plus or minus SD of 2 independent experiments. (D) Weight loss of the recipients. Average weights are shown for mice described in (A) and (B). Data are presented as means plus or minus SD of 2 independent experiments.