Figure 1
Generation of ERG/Gata1s mice. (A) TgERG males were mated with Gata1s knock-in homozygous females to generate animals that express the hERG transgene and the short isoform of GATA1, GATA1s. As GATA1 is located on the X chromosome; male offspring from this cross are all hemizygous and females are all heterozygous for GATA1s. Half of the animals carry the ERG transgene. (B) A table representing the observed vs the expected born mice from the different genotypes. Statistical significance was tested using the Fisher exact test (P < .01 for ERG/Gata1s males and P = .09 for ERG/Gata1s females; n(total) = 137) and the χ2 test (P = .0047).
