Figure 2
![Figure 2. ALK(–)ALCL is molecularly distinct from PTCL-NOS and ALK(+)ALCL. (A) A unique gene expression signature for ALCL was identified and then ALK(+)ALCL cases were separated from ALK(–)ALCL (reclassified ALCL cases are indicated at the top). (B) Representative gene signatures/pathway enriched in ALK(+)ALCL compared with ALK(–)ALCL. (C) A representative re-classified ALCL case (hematoxylin and eosin staining [H&E]) with a pathological diagnosis of PTCL-NOS showing expression of CD30, GZMB, and TIA, but no expression of ALK by immunostaining.](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/123/19/10.1182_blood-2013-11-536359/4/2915f2.jpeg?Expires=1735539817&Signature=z0MrNUjhpxZjP9y6cAXqsT9rXmJvjaJQewVE6y96hfCpfrywrebbjQ2CPwW9KG7oy6Z9S01XYVL8J9wYbtd~ZgOCwx6BYmHQazaGG2tj8VNyVYhON3D-X8psGNakVSiagvOV8ty5Gj~IRDb2gdpWtkFGb5InQ6SFDnREUsCHmI7v2b~fI6QcNWxEVPHEL0~GTQeBXBfE9QUf3HitGFg2ZpaCaGoycur4ktbQ~SDNW43tzTkvq4h56vuLWa9x~8Az5v1T-UQNwmJA0cM9vfZKtC9UT2iT2ZnhaR3NNAYu38EH2Egk3StAeqWpQlZ0lvuJJsYrr9s4V~FXttSI9kYRuA__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
ALK(–)ALCL is molecularly distinct from PTCL-NOS and ALK(+)ALCL. (A) A unique gene expression signature for ALCL was identified and then ALK(+)ALCL cases were separated from ALK(–)ALCL (reclassified ALCL cases are indicated at the top). (B) Representative gene signatures/pathway enriched in ALK(+)ALCL compared with ALK(–)ALCL. (C) A representative re-classified ALCL case (hematoxylin and eosin staining [H&E]) with a pathological diagnosis of PTCL-NOS showing expression of CD30, GZMB, and TIA, but no expression of ALK by immunostaining.
