Talin and kindlin bind to ADAP in resting platelets and are transferred to the β3 cytoplasmic tail after platelet stimulation. Whether intermediary proteins are involved in the associations of ADAP with the platelet membrane and with talin and kindlin is not clear. L, αIIbβ3 ligand; GFFKR, conserved membrane proximal region of the αIIb cytoplasmic tail that helps to maintain inactive αIIbβ3. Adapted with permission from Figure 8 in O'Toole et al.11 © 1994 Rockefeller University Press. Originally published in Journal of Cell Biology. 124:1047-1059. doi:10.1083jcb.124.6.1047.
