TFs that drive erythromegakaryopoiesis. RBCs and MEGs derive from the bipotential MEP. KLF1 and FLI1 regulate lineage determination of the MEP and subsequent erythroid or MEG maturation, respectively. GATA1, TAL1, FOG1, NF-E2, and GFI1B regulate the maturation of both lineages. Germ-line mutations in KLF1 (shown in blue) cause isolated congenital anemia, whereas mutations in the TFs indicated in red affect RBCs and MEGs. Candidate TFs for which no germ-line human mutations have yet been discovered to be associated with anemia or thrombocytopenia are shown in black. Deficiency of FLI1 (shown in green) is associated with thrombocytopenia, but not anemia in Paris-Trousseau syndrome.¹¹²