Figure 2
Figure 2. Analysis of thrombosis and hemostasis in talin1 mutant mice. (A) Tln1W359A/fl Pf4-Cre+ (Tln1WA/flCre+) and Tln1L325R/fl Pf4-Cre+ (Tln1LR/flCre+) mice are protected from FeCl3-induced thrombosis of the carotid artery. Time to vessel occlusion was determined using a Doppler flow probe after 3 minutes of application of 10% FeCl3. (B) The incidence of gastrointestinal bleeding in talin mutant and control mice was determined using a guaiac-based hemoccult test. Numbers of hemoccult-positive/total mice are shown for each group. (C) Bleeding times and (D) blood loss volume in the indicated mice after tail resection (n = 17-56 mice/group). *P < .05, **P < .01, ***P < .001.

Analysis of thrombosis and hemostasis in talin1 mutant mice. (A) Tln1W359A/fl Pf4-Cre+ (Tln1WA/flCre+) and Tln1L325R/fl Pf4-Cre+ (Tln1LR/flCre+) mice are protected from FeCl3-induced thrombosis of the carotid artery. Time to vessel occlusion was determined using a Doppler flow probe after 3 minutes of application of 10% FeCl3. (B) The incidence of gastrointestinal bleeding in talin mutant and control mice was determined using a guaiac-based hemoccult test. Numbers of hemoccult-positive/total mice are shown for each group. (C) Bleeding times and (D) blood loss volume in the indicated mice after tail resection (n = 17-56 mice/group). *P < .05, **P < .01, ***P < .001.

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