Figure 4
The mut-Stat3 mouse lamina propria lymphocytes have altered cytokine expression in response to C rodentium infection. Mean values of cytokine expression (A) in viable CD4+ colonic lamina propria T cells isolated from WT or mut-Stat3 mice 14 days after oral infection with 5 × 109 CFU C rodentium. The mRNA expression of Il22 (B) and its associated antimicrobial peptides (C) were determined by quantitative PCR in the cecums and distal colons from WT or mut-Stat3 mice 14 days after oral infection with 5 × 109 CFU C rodentium. Histograms represent mean values + SEM, data are representative of 2 independent experiments (n = 8 per group). *P < .05; ***P < .001.
