The mut-Stat3 mice were susceptible to LPS-induced septic shock. WT and mut-Stat3 mice were intraperitonally injected with 250 µg LPS, animals were monitored for survival over the following 24 hours. **P = .0015. (A) Serum cytokine measurements by Bead array and ELISA were made 90 minutes after LPS injection (B). Histograms represent mean values + standard error of the mean data were pooled from 2 experiments (n = 10 per group). CD11c⁺ splenocytes from WT and mut-Stat3 mice were stimulated with either LPS or LPS and IL-10 for 24 hours. Gene expression by Affymetrix microarray comparing LPS and LPS+IL-10 treated WT CD11c⁺ cells is shown as a scatter plot (C). Genes that had a greater than twofold change in gene expression between conditions were defined as IL-10 responsive genes (indicated by the thick green lines). Two dimensional cluster analysis of the IL-10 responsive gene list is presented (D). Each row corresponds to a transcript and each column to the mean expression values of a sample, pooled from 3 independent microarrays. The color denotes Log₁₀ raw intensity value (blue: 1–red: 4). *P < .05; **P < .01.