NK cell activation induced through CD16 crosslinking is intact in MDS-NK cells. (A-C) Resting PBMCs from normal donors and MDS patients were coated with 10 μg/mL of the indicated mAbs and cocultured with P815 targets, and an R-ADCC assay was performed. NK cell CD107a expression (A) and intracellular TNF-α (B) and IFN-γ (C) production were evaluated by FACS analysis (*P < .05, ***P < .001, ****P < .0001). mIgG, mouse immunoglobulin G.