Impaired developmentally programmed apoptosis in mice lacking Bim and Bmf. Bim and Bmf mediate the removal of interdigitating mesenchymal cells in (A) WT, (B) Bim^−/−, and (C) Bmf^−/− mice, whereas (D-E) Bim^−/−Bmf^−/− mice present with soft tissue syndactyly, (G) vaginal aplasia, and (I) malocclusion of the incisors, (A,F,H) phenotypes that are not or only rarely observed in single knockout mice or WT control animals.