Hematopoietic cell types cluster together based on the expression of different epigenetic factors. (A) Table listing the different hematopoietic cell types used in this study. Progenitor cells, lymphoid, and myeloid lineages are shown in red, purple, and black, respectively. Mast cells and dendritic cells (DCs) of myeloid and lymphoid origin are indicated in green. (B) A general scheme of interdependence of different classes of epigenetic factors involved in regulating gene expression. Some of these factors modulate DNA/histone modifications, whereas chromatin remodeling complexes (CRCs) alter chromatin structure to either expose or conceal transcription factor (TF) binding sites. The polycomb complexes interact with DNA/histone modifying factors to regulate the gene expression at the chromatin level. (C) Principal component analysis (PCA) based on expression levels of 199 epigenetic factors in different hematopoietic cell types. Progenitor cells (red dots), lymphoid cells (purple dots), myeloid cells (black dots), mast cells, DC plasma, and DC monocytes (green dots). (D) Unsupervised hierarchical cluster analysis of the different hematopoietic cell types from individual donors (biological replicates) based on the expression of 199 epigenetic factors.