PAR-1 and thromboxane receptors do not mediate TCIPA or TCIPS. (A-C) Representative aggregation traces showing the effect of the reported inhibitors on TRAP (10 μM; A)– or PC3M-luc (100 × 10³ cells per mL; B-C)–induced platelet aggregation. (D-E) Bar graph comparing the effect of the indicated inhibitors on platelet aggregation (n = 3/9) and secretion (n = 6/10) elicited by TRAP or PC3M-luc. Results were normalized for each donor relative to the maximal response seen in TRAP- or PC3M-luc–stimulated platelets (100%) in presence of the vehicle solution (data are expressed as mean ± SEM; *P < .05; ***P < .0001).