PI3K and Src kinase are specifically activated during TCIPA, whereas FAK kinase function is required in TCIPS and TCIPA. (A) Representative aggregation trace showing the effect of inhibitors of Syk, PI3K, and FAK on PC3M-luc (100 × 10³cells per mL) induced platelet aggregation. (B) Bar graph comparing the effect of the indicated inhibitors on platelet aggregation (n = 4/7; *P < .05; ***P < .0001) and dense-granule secretion (n = 4/7; *P < .05) elicited by PC3M-luc. Results are expressed and normalized for each donor as explained in the Figure 3 legend (data are expressed as mean ± SEM).