BM disease involvement and serum IgM levels at diagnosis for WM patients stratified by MYD88 and CXCR4 mutation status. MYD88WTCXCR4WT (n = 15), MYD88L265PCXCR4WT (n = 109), MYD88L265PCXCR4WHIM/FS (n = 24), and MYD88L265PCXCR4WHIM/NS (n = 26). Box plots with interquartile ranges are shown with an overlay of the individual data points.