Emerging targets for thrombus prevention and thrombolysis. Here we summarize advances in the field of thrombosis with respect to neutrophil recruitment and NETosis and pinpoint targets that should be investigated as potential therapeutics (black). Existing treatments are in gray. We propose PAD4 inhibition as a way to prevent NET release. For thrombi that have already formed, neutralizing the toxic components of NETs is key. Thrombolytic strategies should involve the targeting of both DNA (blue) and the protein elements (red and green) of the thrombus scaffold.