Effects of TKIs on ADCC. (A) ADCC by Cr⁵¹ assay with variable E:T ratios using ESKM vs IgG1 isotype control. The effects of imatinib (B) and dasatinib (C) on ADCC. No significant effect on ADCC by imatinib was seen on human PBMC-mediated ADCC in concentrations as high as 10 µM. Dasatinib inhibited human PBMC-mediated ADCC starting at concentrations of 10 nM.