Blockade of the GpIbα-VWF interactions remains efficient one hour after thrombus formation in the MCA and after occlusive thrombosis of the CCA. (A) Representative laser Doppler profiles of mice treated with ATA (20 mg/kg) 20 minutes, 1 hour, or 4 hours post-MCAo. Control animals received saline 1 hour post-MCAo. (B) Mean CBF of mice treated with saline or ATA at different time points. (C) Representative T2-weighted images of saline- and ATA-treated mice 24 hours after FeCl₃ application. (D) Corresponding quantification of lesion sizes. (E) Representative laser Doppler profiles of mice treated with saline, ATA (20 mg/kg), or GR (10 mg/kg) 20 minutes postocclusion of the CCA. (F) Mean blood flow of mice treated with saline, ATA, or GR 20 minutes postocclusion of the CCA (n = 4/group). ns, not significant.