Figure 3
Figure 3. Allogeneic platelet transfusions inhibit T-cell–mediated ITP. Platelet counts in SCID mice transferred with CD19-depleted CD61 KO immune splenocytes against BALB/c (CD61+/H-2d) platelets and then transfused weekly with either nothing (○; N = 5), syngeneic BALB/c platelets (▼; N = 5), or allogeneic C57BL/6 platelets (□; N = 5). Results are presented as the weekly platelet counts (×109/L) after splenocyte transfer (*P < .05 for □ vs ○).

Allogeneic platelet transfusions inhibit T-cell–mediated ITP. Platelet counts in SCID mice transferred with CD19-depleted CD61 KO immune splenocytes against BALB/c (CD61+/H-2d) platelets and then transfused weekly with either nothing (○; N = 5), syngeneic BALB/c platelets (▼; N = 5), or allogeneic C57BL/6 platelets (□; N = 5). Results are presented as the weekly platelet counts (×109/L) after splenocyte transfer (*P < .05 for □ vs ○).

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