Explorative subset analyses according the NPM1 mutational status. (A) RFS in AML with mutated NPM1. (B) RFS in AML with NPM1 wild-type. (C) OS in AML with mutated NPM1 in first CR. (D) OS in AML with NPM1 wild-type in first CR. (E) Forest plots showing hazard ratios for death or relapse (relapse-free survival), as well as death (OS) and 95% confidence intervals (bars) for 75 patients with AML in first CR.