![Figure 1. PVM infection in the cytokine-driven B6-E2IL5tg mouse model of airway inflammation. (A) Total eosinophils in BAL fluid from PVM-infected C57BL/6 (B6) wild-type, B6-eotaxin-2/IL-5 double transgenic (B6-E2IL5tg), eosinophil-deficient B6-ΔdblGATA, and cytokine-enriched eosinophil-deficient B6-E2IL5tg-ΔdblGATA mice; t = 4 days after PVM inoculation; n = 4 to 6 mice per time point; ***P < .0001 (1-way analysis of variance [ANOVA]). (B) Cell differentials of mice described in A. (C-D) Microscopic histology of lung tissue from PVM-infected B6-E2IL5tg mice; original magnifications ×10 and ×40, respectively. (E-F) Microscopic histology of lung tissue from PVM-infected B6-E2IL5tg-ΔdblGATA mice; original magnifications ×10 and ×40, respectively; area within box in (E) magnified as shown in (F).](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/123/5/10.1182_blood-2013-05-502443/4/743f1.jpeg?Expires=1735818424&Signature=rWjJrWE3v2WeOXCz8pnXK~urtpVf10nMX78K7rijt3fcvsZHxNSBT51kI5KoOrZBP5-BMXoEGsvUEr4eWLndTaJYWkVy2~TH43vvtHOKRFEtoeYyU1OjMHnxZzi4eN4EtM5Cr1ywQXMgEZjjZNHEDwbObhgPLXo32-flABHZ35F5imLlg9fqdA9BnMuYucr6Q8AW~kCkkdPs2DavIpyits5Sgpr3coYAurU438T0bC8p0aek8GUhls4hJMEISarJDimeExXLtGiJ8GIeJ1473i-3MlpIrmDSMwWpCVcZZohGofRGitpRcvn8CQri22lsy0~Cs5un-V2~WB-cfHqjyA__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
PVM infection in the cytokine-driven B6-E2IL5tg mouse model of airway inflammation. (A) Total eosinophils in BAL fluid from PVM-infected C57BL/6 (B6) wild-type, B6-eotaxin-2/IL-5 double transgenic (B6-E2IL5tg), eosinophil-deficient B6-ΔdblGATA, and cytokine-enriched eosinophil-deficient B6-E2IL5tg-ΔdblGATA mice; t = 4 days after PVM inoculation; n = 4 to 6 mice per time point; ***P < .0001 (1-way analysis of variance [ANOVA]). (B) Cell differentials of mice described in A. (C-D) Microscopic histology of lung tissue from PVM-infected B6-E2IL5tg mice; original magnifications ×10 and ×40, respectively. (E-F) Microscopic histology of lung tissue from PVM-infected B6-E2IL5tg-ΔdblGATA mice; original magnifications ×10 and ×40, respectively; area within box in (E) magnified as shown in (F).
