Eosinophils in the B6-E2IL5tg mouse airway inflammation model are antiviral and promote survival in response to a lethal respiratory virus infection. (A) Virus recovery t = 4 days after inoculation with PVM, determined as absolute copy number of virus SH gene per absolute copy number cellular GAPDH (PVM_SH/GAPDH) in samples of total lung RNA; ***P < .001 (1-way ANOVA). (B) Cell differential at t = 4 days after adoptive transfer of eosinophils isolated from BAL fluid of B6-E2IL5tg mice (or vehicle alone) into the airways of recipient cytokine-enriched, eosinophil-deficient B6-E2IL5tg-ΔdblGATA mice immediately prior to inoculation with PVM. (C) Virus recovery (PVM_SH/GAPDH from experiment described in (B); **P < .03 (Mann-Whitney, 2-tailed). (D) Survival of mice inoculated on day 0 with PVM, n = 5 to 10 mice per group; ***P < .001 (log-rank).