Deficiency of ADAM10 abrogates alveolar leukocyte recruitment in LPS-induced acute pulmonary inflammation. (A-C) Vav-Adam10^−/−, Vav-Adam17^−/− mice, and respective litter controls were intranasally treated with 400 µg/kg LPS or vehicle (PBS). After 24 hours, lungs were lavaged, and BAL fluid was investigated for (A) content of leukocytes, (B) neutrophils, and (C) monocytes by flow cytometry. Results are expressed as cell number per milliliter of BAL fluid. Data represent means ± SEM (n = 5). Significance was calculated using 1-way ANOVA and the Bonferroni post-test and is indicated by crosses. Crosses without a line indicate significance to the PBS-treated control.