ADAM10 deficiency attenuates LPS-induced acute pulmonary inflammation. (A-C) Vav-Adam10^−/−, (D-F) Vav-Adam17^−/−, (G-I) LysM-Adam10^−/−, and respective litter control mice were intranasally treated with 400 µg/kg LPS or vehicle (PBS). After 72 hours, lungs were lavaged, and BAL fluid was analyzed for content of (A,D,G) neutrophils and (B,E,H) monocytes by flow cytometry. Results are expressed as cell number per milliliter of BAL fluid. (C,F,I) After 72 hours, lung wet-dry-ratio was determined. Data represent means ± SEM (n = 5). Significance was calculated using 1-way ANOVA and the Bonferroni post-test and is indicated by crosses. Crosses without a line indicate significance to the PBS-treated control.