Working model for differentiation of hemangioblasts in zebrafish with the acting position of aggf1 indicated. Genes involved in the generation of both hematopoietic and endothelial lineages in zebrafish embryos are indicated. This study suggests that aggf1 acts as the earliest gene that affects the differentiation of hemangioblasts. Modified from H. Yamauchi et al,⁴⁷  Zhang et al,⁴⁸  and Bertrand et al.⁴⁹