Impact of NOTCH1 mutations on integrin expression in trisomy 12 CLL. The impact of NOTCH1 mutation status on integrin expression was assessed in a cohort of separate cohort of 15 trisomy 12 CLL patients with known NOTCH1 mutation status.¹  Notably the expression of CD11a (A), CD11b (B), and CD18 (C) was significantly reduced in trisomy 12 CLL cells with a NOTCH1 mutation compared with trisomy 12 CLL cells with wild-type NOTCH1 genes. NOTCH1 mutation status had no impact on the expression of CD29 (D), CD49d (E), or ITGB7 (F).