Genotype-phenotype associations. Kaplan-Meier curves are shown for patients with missense (green, N = 33), null (red, N = 12), and regulatory mutations (blue, N = 9). Patients with uniallelic expression (N = 3) are not shown. Mutation group was associated with the risk for viral infection (P = .038) and lymphedema (exact log-rank test P = .006). No other end points differed by mutation group. Unless otherwise noted, P values were calculated using Cox regression stratified on proband status, with robust standard errors to adjust for kindred clusters.