Blood counts and disease severity. Absolute B cell, NK cell, monocyte, and CD4⁺ T cell count at first NIH visit for patients with 0, 1, 2, 3, or 4 of the following major complications: MDS/leukemia, severe viral infection, disseminated mycobacterial or fungal infection, and PAP. Monocyte counts and lymphocyte phenotyping were available for 55 and 51 patients, respectively. Shaded regions indicate normal blood count ranges from the NIH Department of Laboratory Medicine: absolute CD20⁺ B cell count 60 to 539 cells/μL; absolute NK cell count 126 to 729 cells/μL; absolute monocyte count 0.24 to 0.86 x10³ cells/μL; and absolute CD4⁺ T-cell count 362 to 1275 cells/μL. Diamonds indicate individuals with monocytosis in the setting of CMML. Horizontal bars indicate medians. Vertical bars indicate interquartile ranges. Blood counts were significantly associated with the number of major complications (P < .001). P values were obtained using linear regression with robust standard errors to adjust for kindred clusters. Analysis was done for the log-transformed cell counts, with offsets of half the lower limit of detection for B cells, NK cells, and monocytes to account for those cases in which the numbers were zero.