RBC production and lifespan are decreased in BA-treated mice. (A) Percentage of biotinylated RBCs, (B) total RBC number, and (C) biotinylated RBC number in WT, IL-6-KO, and Hamp-KO mice injected with BA or PBS. We analyzed between 5 and 7 mice for each group. Each time point in BA-treated mice was compared with the same time point in PBS-treated mice in A and C. P values were calculated using unpaired, 2-tailed Student t test. *P < .05; **P < .01; ***P < .001.