TxB₂concentration in plasma supernatants from healthy volunteers and patients with bleeding symptoms. TxB₂ concentration adjusted for platelet count in healthy volunteers with normal (n = 20) or impaired (n = 5) AA response on Optimul and in patients with bleeding disorders with normal (n = 18) or impaired (n = 17) AA response on Optimul. Line and whiskers represent median and interquartile range; the gray band represents the normal range derived from bank of healthy volunteers.