Pattern of platelet responses obtained with Optimul. (A) Dose-response curves presented as median and interquartile range. Open squares represent healthy volunteers, the striped squares represent patients with bleeding symptoms in whom no defect was found on LTA, and red lozenges represent patients in whom a secretion defect was found on LTA. (B) Dose-response curves presented as median and interquartile range. Open squares represent healthy volunteers, the striped squares represent patients with bleeding symptoms in whom no defect was found on LTA, and green circles represent patients in whom a thromboxane pathway defect was found on LTA. (C) Dose-response curves presented as median and interquartile range. Open squares represent healthy volunteers, the striped squares represent patients with bleeding symptoms in whom no defect was found on LTA, and blue triangles represent patients in whom a G_i-type defect was found on LTA. (D) Summary of finding presented as AUC for each of the types of platelet phenotypes defined by LTA. Data presented as median and interquartile range; the whiskers represent the 5th and 95th percentiles.