Figure 4
Figure 4. Zebra fish as a DBA model of the RPS29 mutations. (A) The Hb phenotype of zebra fish embryos with WT rps29+/+, rps29−/− uninjected embryos, rps29−/− embryos injected with WT human RPS29 RNA, and rps29−/− embryos injected with the p.I31F mutant human RPS29 RNA from the proband (III-3) in family NCI-193. The numbers of zebra fish embryos displaying this phenotype are shown (ie, 9 of 25 injected and 21 of 21 injected). (B) The percent of rps29−/− zebra fish embryos with high Hb are shown for the uninjected embryos, WT human RPS29 RNA–injected embryos, and the p.I31F mutant human RPS29 RNA–injected embryos. (C) The Hb phenotype of embryos injected with the p.I50T mutant human RPS29 RNA. (D) The percent of embryos with high Hb. *Student t test P < .05; **Student t test P < .01.

Zebra fish as a DBA model of the RPS29 mutations. (A) The Hb phenotype of zebra fish embryos with WT rps29+/+, rps29−/− uninjected embryos, rps29−/− embryos injected with WT human RPS29 RNA, and rps29−/− embryos injected with the p.I31F mutant human RPS29 RNA from the proband (III-3) in family NCI-193. The numbers of zebra fish embryos displaying this phenotype are shown (ie, 9 of 25 injected and 21 of 21 injected). (B) The percent of rps29−/− zebra fish embryos with high Hb are shown for the uninjected embryos, WT human RPS29 RNA–injected embryos, and the p.I31F mutant human RPS29 RNA–injected embryos. (C) The Hb phenotype of embryos injected with the p.I50T mutant human RPS29 RNA. (D) The percent of embryos with high Hb. *Student t test P < .05; **Student t test P < .01.

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