Reduced thrombin generation in normal plasma after the addition of TM. Thrombin generation triggered by 1 pM TF was measured in normal plasma (●), and in normal plasma following the addition of recombinant human C-terminal truncated TM to a final concentration of 3.75 nM 250 ng/ml (▪), 7.5 nM (500 ng/ml) (♦), and 15 nM (1000 ng/ml) (▲).