Possible roles of 12-LOX in platelet activation through FcγRIIa. 12-LOX may enhance platelet activation induced by ligation of FcRγIIa through either 12-HETE generated from AA, through its receptor GPR31, or via an interaction involving PLCγ2 and/or upstream signaling and adaptor molecules such as Syk (spleen tyrosine kinase), PI₃K (phosphinositide 3-kinase), and LAT (linker for activation of T cells). DAG, diacyl glycerol; IP₃, inositol triphosphate; PLA2, phospholipase A2.