Schematic model of GATA1/Foxo3-exosome complex network. Exosome complex components create an erythroid barricade at the early stage of erythropoiesis. During the process of GATA1/Foxo3-induced erythroid maturation, GATA1 directly upregulates Foxo3 and functions together to repress the expression of exosome complex components, thus abrogating the blockade and allowing the erythroid maturation to proceed. The figure has been adapted from Figure 7 in the article by McIver et al that begins on page 2285.