Activation of the SUMOylation pathways is a hallmark of human BL. (A) The expression of components of the SUMOylation pathway was analyzed in the gene expression data set GSE4475, comparing mBL with non-mBL samples.40 (B-M) Tissue microarrays of BL, DLBCL, mantle cell lymphoma (MCL), and follicular lymphoma (FL) were evaluated for SUMO2/3 expression using immunohistochemistry. (B) BL hematoxylin and eosin (H&E) staining. (C-D) BL SUMO2/3 positive. (E) FL H&E staining. (F) SUMO2/3-positive FL. (G) SUMO2/3-negative FL. (H) MCL H&E staining. (I) SUMO2/3-positive MCL. (J) SUMO2/3-negative MCL. (K) DLBCL H&E staining. (L) SUMO2/3-positive DLBCL. (M) SUMO2/3-negative DLBCL. Representative cases are shown. (N) Quantification of SUMO2/3 positivity in the indicated human B-cell lymphoma samples.
