SS RBC-derived MPs enhance endothelial adhesion, express LW, and express more p-ERK1/2 than AA RBC-derived MPs. (A) RBC-derived MPs were incubated with primary AA PBMCs at 3 different concentrations (low, medium, and high) for 18 hours before HUVEC adhesion. Representative fluorescent images show adherent DRAQ5-labeled THP-1 cells after 4 hours of adhesion to HUVECs. (B) AAMPs and SSMPs express surface ICAM-4 (LW). (C-D) p-ERK1/2 is significantly elevated in SSMPs relative to AAMPs (n = 6). P < .05 measured in ANOVA relative to vehicle or AAMPs.