During recovery from BA-induced anemia, Erfe-deficient mice show delayed and more iron-restricted reticulocytosis than WT mice. Absolute reticulocyte count (A) was significantly increased on day 14 only in WT mice, but by day 21, Erfe-deficient mice had higher reticulocyte count than WT mice. Using the forward scatter as an assessment of the reticulocyte size (B), we found that both WT and Erfe^−/− mice injected with BA were producing smaller cells than their respective saline controls. Erfe^−/− mice produced even smaller reticulocytes than WT at days 14, 21, and 28 (B). Data shown are means ± SEM and were compared for each time point within the same genotype between saline and BA-treated mice by 2-tailed Student t test (*P < .05, ***P < .001). Values were also compared at each time point between WT and Erfe-deficient mice (n = 6 per time point) by 2-tailed Student t test (^###P < .001).