miR-146a in human GVHD. (A-B) The rs2910164 SNP genotype was analyzed in 286 HCT donors using Taqman realtime PCR assays. (A) Frequency of donors with the CC genotype vs the non-CC genotype in the group of patients with no/mild GVHD (grade 0-II) and severe GVHD (grade III-IV), respectively, is shown. Frequency of the CC genotype was higher in HCT donors of patients developing severe GVHD compared with no/mild GVHD. (B) Mean GVHD severity in recipients that have received hematopoietic cells from allogeneic donors with the CC genotype vs without the CC genotype is shown.