Three typical patterns of posttreatment anemia in 42 nontransfused patients with severe malaria treated with AS and monitored for more than 8 days. (A1-A3). Mean and standard error of the mean (SEM; vertical bars) of (solid red circles) blood hemoglobin level and (empty red circles) blood reticulocyte count per 10 g/L on day 0, day 2 ± 1, day 7 ± 2, day 14 ± 3, day 21 ± 3, and day 28 ± 3 in subgroups of patients categorized according to their evolution pattern as (A1) rising, (A2) persistent, or (A3) PADH, as defined in the “Materials and methods” section. At least 2 samples were collected before and after day 8 in each patient. (B1-B3) Mean and SEM of (solid black diamonds) plasma LDH 10 IU/L and (solid grey squares) haptoglobin levels (×15 g/L) in the same subgroups. The blood hemoglobin level was normalized against the hemoglobin level on day 0. The delayed drop in hemoglobin levels in patients with PADH is indicated by a black arrow.