Duration of very severe neutropenia (<0.2 × 109/L) after Cy and voriconazole levels. (A) The average duration of very severe neutropenia was 70 days (range, 15 to 240 days) for the entire cohort, whereas for responders it was 36 days (range, 15 to 64 days), and for nonresponders, it was 94 days (range, 20 to 240 days). (B) The average voriconazole level for the entire cohort was 2.4 mg/L (range, 0.47 to 8.130 mg/L), among responders, it was 1.3 mg/L (range, 0.47 to 2.9 mg/L), and among nonresponders, it was 3.2 mg/L (range, 1.1 to 8.1 mg/L). Each data point represents the average voriconazole level for each patient throughout the duration of very severe neutropenia. The target voriconazole level was 1 to 5.5 mg/L (dotted lines). The patients who required granulocyte transfusions for uncontrolled infections despite maximum antimicrobial support are depicted in red. ANC, absolute neutrophil count.
