Clonal evolution, late events (relapse + clonal evolution), and survival rates following Cy + CsA. (A) The cumulative incidence of clonal evolution at 1 year was 22% (95% CI, 0% to 39%). (B) An additional 2 patients relapsed, bringing the total incidence of late events (relapse + clonal evolution) to 28% (95% CI, 4% to 46%) at 2 years. (C) The 2-year survival for this cohort was 72% (95% CI, 55% to 94%). Day 0 in this survival curve is the first day of Cy. Dotted lines represent 95% confidence intervals.