Figure 4
Figure 4. Hoxa genes and RASA2 are differentially expressed between t(6;11) patients and HBM cells. (A) Hierarchical clustering analysis of 11 patients with t(6;11) (blue) and 11 healthy bone marrow (orange). (B) Box-plot of RASA2 probe sets in t(6;11)-patients (white) vs HBM (gray) samples generated using Partek Genomic Suite Software 6.6. Expression values are indicated in the boxes as the median of each group. Y-axis probe set expression values in log2 scale. (C) Histogram confirmed the decreased messenger RNA levels of RASA2 by qRT-PCR (ΔΔCt method) in 11 MLL-AF6 rearranged patients. Results are calibrated to the 11 HBM (RQ = 1). (D) Box-plot of RASA2 probe sets in t(6;11)-patients vs MLL-other leukemic samples generated using Partek Genomic Suite Software. Expression values are indicated in the boxes as the median of each group. Y-axis probe set expression values in log2 scale. *P < .05.

Hoxa genes and RASA2 are differentially expressed between t(6;11) patients and HBM cells. (A) Hierarchical clustering analysis of 11 patients with t(6;11) (blue) and 11 healthy bone marrow (orange). (B) Box-plot of RASA2 probe sets in t(6;11)-patients (white) vs HBM (gray) samples generated using Partek Genomic Suite Software 6.6. Expression values are indicated in the boxes as the median of each group. Y-axis probe set expression values in log2 scale. (C) Histogram confirmed the decreased messenger RNA levels of RASA2 by qRT-PCR (ΔΔCt method) in 11 MLL-AF6 rearranged patients. Results are calibrated to the 11 HBM (RQ = 1). (D) Box-plot of RASA2 probe sets in t(6;11)-patients vs MLL-other leukemic samples generated using Partek Genomic Suite Software. Expression values are indicated in the boxes as the median of each group. Y-axis probe set expression values in log2 scale. *P < .05.

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