Kaplan-Meier estimates of OS. (A) OS according to FLT3/ITD and NUP98/NSD1 status and (B) OS in CN-AML according to FLT3/ITD and NUP98/NSD1 status. NUP98/NSD1⁺ (NUP98/NSD1 present), NUP98/NSD1⁻ (NUP98/NSD1 absent), FLT3/ITD⁺ (FLT3/ITD present), and FLT3/ITD⁻ (FLT3/ITD absent).