Antiglycoprotein E humoral and cell-mediated immune response rates. Shown are the percentages of subjects with humoral (A) and cell-mediated (B) immune responses against VZV glycoprotein E. A humoral response was defined as a greater than or equal to fourfold increase in GMC in subjects who were seropositive before vaccination or a GMC ≥4 times the cutoff value in subjects seronegative before vaccination. A cell-mediated immune response was defined as a greater than or equal to twofold increase in CD4(2⁺) T-cell frequency over prevaccination. Bars indicate means, and errors bars indicate 95% confidence intervals. gE/AS01_B indicates glycoprotein E/liposome-based adjuvant (50 µg MPL, 50 µg QS21); and gE/AS01_E, glycoprotein E/liposome-based adjuvant (25 µg MPL, 25 µg QS21).