Flow diagram of 300 patients with CLL receiving frontline chemotherapy with FCR. The present analysis focuses on the outcome of 156 patients with relapsed (n = 143) or refractory (n = 13) disease. MDS, myelodysplastic syndrome; AML, acute myeloid leukemia; T-ALL, T-cell acute lymphoblastic leukemia; T-LGL, T-cell large granular lymphocytic leukemia.