(A) Non-TCR partners of 3 cases of T-ALL (nos. 1, 4, and 7 from Table 1) with MYC translocations. Mapping of superenhancers at 1q32, 7q21, and Xq25 were indicated with 3 vertical thin bars. (B) MYC expression in 83 cases of pediatric T-ALL and in 8 MYC translocation–positive T-ALL (nos. 1-4, 9-12 from Table 1). Cases with translocations had a significantly higher MYC expression. (C) Circos plot shows distribution of MYC translocations according to genetic categories. MYC translocation–positive T-ALL clustered into the TAL/LMO category; (D) Supervised gene expression profiling analysis of 13 TAL/LMO-positive T-ALL with high MYC expression at diagnosis (Q4): 6 cases with MYC translocations (nos. 1-4, 9, 10; Table 1) clustered together and separated from the 7 cases without. (E) Q4 TAL/LMO-positive T-ALL: CD44 expression was higher in T-ALL cases with MYC translocation compared with cases without. (F) NOTCH1 expression was significantly lower in cases with MYC translocations compared with cases without. (G) Longitudinal FISH studies in 2 cases: in case no. 11 the clone with MYC translocation was not detected at diagnosis but only at relapse (left); in case no. 12, the small subclone (∼8%) with the MYC translocation present at diagnosis was found in 100% of leukemic blasts at relapse. Q4, fourth quartile.