Overall survival by novel prognostic score, IPI, and R-IPI. Kaplan-Meier curves demonstrating overall survival (OS) by (A) a novel prognostic score among 201 patients with all data available; by (B) the original international prognostic index (IPI); and by (C) the R-IPI, for patients with DLBCL treated in the rituximab era. In the novel prognostic score, patients are assigned one point for each of the following: leukocytosis, lactate dehydrogenase >3× ULN, Ann Arbor stage 3 or 4 disease, and CNS involvement.