The relative amount of active TIF-90 complexes correlates with rRNA synthesis and thus proliferation. Akt activity affects the balance of complexes by modulating FLNA cleavage as described in the text. Given that no assays with purified protein have been carried out, it is unknown whether TIF-90 directly binds to either Pol I or FLNA-C, thus the illustration is not meant to imply direct interactions. Professional illustration by Luk Cox, Somersault1824.