TAK1 expression is increased in AML CD34⁺ cell vs NBM CD34⁺ cells. (A) Gene set enrichment analysis profiles generated from the AML CD34⁺ vs NBM CD34⁺ gene list.²²  (B) There were 25 most significantly upregulated apoptosis-associated genes in AML CD34⁺ cells vs NBM CD34⁺ cells. (C) Relative expression of TAK1 in all individual AML CD34⁺ and NBM CD34⁺ samples analyzed by gene profiling. (D) Relative expression of TAK1 AML CD34⁺ and NBM CD34⁺ cells by using quantitative polymerase chain reaction. (E) Relative protein levels of TAK1 in 2 AML CD34⁺ cells expressing high RNA levels of TAK1 and 2 AML CD34⁺ cells expressing low RNA levels of TAK1. ES, enrichment score; FDR, false discovery rate; GSEA, gene set enrichment analysis; NES, normalized enrichment score; NOM, nominal P value.