Distribution of differentiation subsets among ALPS and control DNT, according to CCR7 and CD45RA expression. (A) Representative plots showing CCR7 and CD45RA expression of ALPS vs control DNT. (B) Distribution of naïve (naïve, CCR7⁺CD45RA⁺), central memory (CM, CCR7⁺CD45RA⁻), effector memory (EM, CCR7⁻CD45RA⁻), and terminal differentiated T cells reexpressing CD45RA (TEMRA, CCR7⁻CD45RA⁺) among DNT (gate: CD3⁺TCRαβ⁺CD4⁻CD8⁻) of all studied ALPS patients (ALPS all), adult ALPS patients (ALPS >18 y), and adult controls (Con >18 y). Because pediatric and adult patients had a similar distribution, statistical comparison was performed between all ALPS patients and adult controls. ns, not significant. *P < .05; **P < .01; ***P < .001.